4-苯基双环[2.2.2]辛烷-1-羧酸合成路线 （共 5 条）
反应条件
sulfuric acid in dichloromethane 24 h; Heating;
参考文献
Adcock, William; Kok, Gaik B.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1079 - 1087
反应条件
1: H2SO4 / CH2Cl2 / 24 h / Heating 2: 78 percent Turnov. / NaIO4, RuCl3*H2O / H2O; acetonitrile; CCl4 / 96 h / Ambient temperature View Scheme
参考文献
Adcock, William; Kok, Gaik B.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1079 - 1087
反应条件
1: With methanol; sodium hydroxide; water in tetrahydrofuran
T=20°C;
2: With hydrogenchloride; water in tetrahydrofuran
pH=2;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/71966 A1, 2007 ;
Location in patent: Page/Page column 36 ;
WO 2007/071966 A1
反应条件
1: Py / 210 °C
2: KOH / aq. ethanol
View Scheme
参考文献
Holtz,H.D.; Stock,L.M.
Journal of the American Chemical Society, 1964 , vol. 86, p. 5183 - 5188
反应条件
1: H2SO4 / CH2Cl2 / 24 h / Heating
2: 78 percent Turnov. / NaIO4, RuCl3*H2O / H2O; acetonitrile; CCl4 / 96 h / Ambient temperature
3: BH3*(CH3)2S / tetrahydrofuran
View Scheme
参考文献
Adcock, William; Kok, Gaik B.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1079 - 1087
