3-[3-(三氟甲基)苯基]丙腈合成路线 （共 6 条）
反应条件
manganese; water; trifluoroacetic acid; Co(2,2'-bipyridine)Br2; lithium bromide in pyridine; N,N-dimethyl-formamide T=50°C;
参考文献
Amatore, Muriel; Gosmini, Corinne; Perichon, Jacques
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 6130 - 6134
反应条件
1: With acetic acid; zinc in water T=20 - 65°C; 4.5 h; 2: With hydrogenchloride in water; toluene 0.166667 h; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2008/35381 A2, 2008 ;
Location in patent: Page/Page column 25 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 9 h;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 1 p. 55 - 69
反应条件
nickel in ethylene glycol dimethyl ether T=85°C; 0.25 h;
参考文献
Inaba, Shin-ichi; Rieke, Reuben D.
Synthesis, 1984 , # 10 p. 842 - 844
反应条件
1: ammonium acetate, pyridine / pyridine; toluene / 44 h / Heating 2: H2 / 5percent Pd/C / ethanol / 9 h / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 1 p. 55 - 69
反应条件
hydrogenchloride; water 4.5 h; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2008/35381 A2, 2008 ;
Location in patent: Page/Page column 26 ;
