3-氨基-6-氯吡啶-2-甲腈合成路线 （共 6 条）
反应条件
1: With hydrogenchloride; iron in ethanol; water 0.5 h; Reflux; 2: With ammonia in diethyl ether; ethanol
参考文献
SHENYANG PHARMACEUTICAL UNIVERSITY
Patent: US2011/183972 A1, 2011 ;
Location in patent: Page/Page column 12-13 ;
US 20110183972 A1
反应条件
hydrogenchloride in methanol; water
参考文献
Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6399593 B1, 2002 ;
反应条件
1: NMP / 180 °C 2: Fe, HCl / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 23 p. 4533 - 4541
反应条件
1: in dimethylsulfon
T=165°C; 0.5 h;
2: With sodium hydroxide in dimethylsulfon; water
T=20°C; pH=9 - 10;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 99; 1/6; 4/6 ;
反应条件
1: 57 percent / various solvent(s) / 0.17 h / 165 - 190 °C
2: 83 percent / various solvent(s) / 1 h / 195 °C
3: 72 percent / Bromine complex of 1,4-diazabicyclo<2.2.2>octane / aq. acetic acid / 19 h / Ambient temperature
View Scheme
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
反应条件
1: 57 percent / various solvent(s) / 0.17 h / 165 - 190 °C
2: 50 percent / various solvent(s) / 1 h / 195 °C
3: 59 percent / Bromine complex of 1,4-diazabicyclo<2.2.2>octane / aq. acetic acid / 19 h / Ambient temperature
View Scheme
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
