N-甲氧基-n-甲基烟酰胺合成路线 （共 20 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in acetonitrile
T=20°C; 2 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/124447 A2, 2006 ;
Location in patent: Page/Page column 77 ;
WO 2006/124447 A2
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Zhang, Gang; Kumamoto, Takuya; Heima, Takashi; Ishikawa, Tsutomu
Tetrahedron Letters, 2010 , vol. 51, # 30 p. 3927 - 3930
反应条件
pyridine in dichloromethane
T=0 - 20°C; 4.25 h;
参考文献
SOLVAY PHARMACEUTICALS B.V.
Patent: WO2008/129054 A2, 2008 ;
Location in patent: Page/Page column 28 ;
反应条件
1: [3H]-Nicotinic acid With thionyl chloride
1 h; Reflux;
2: N,O-dimethyl-hydroxylamine With triethylamine in dichloromethane
T=20°C; 1.5 h;
参考文献
NOVARTIS AG
Patent: WO2009/156462 A2, 2009 ;
Location in patent: Page/Page column 78-79 ;
反应条件
O,N-dimethyl-hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane
T=20°C; 75 h;
参考文献
Burns, Christopher J.; Harte, Michael F.; Bu, Xianyong; Fantino, Emmanuelle; Joffe, Max; Sikanyika, Harrison; Su, Stephen; Tranberg, C. Elisabet; Wilson, Neil; Charman, Susan A.; Shackleford, David M.; Wilks, Andrew F.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4639 - 4642
反应条件
in tetrahydrofuran
T=20°C; 1 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; BROWN, Jason, W.; KEUNG, Walter; LI, Zhe; TYHONAS, John
Patent: WO2010/111634 A2, 2010 ;
Location in patent: Page/Page column 151-152 ;
WO 2010/111634 A2
反应条件
in tetrahydrofuran
T=0 - 20°C; Grignard addition; 2 h;
参考文献
Burns, Christopher J.; Harte, Michael F.; Bu, Xianyong; Fantino, Emmanuelle; Joffe, Max; Sikanyika, Harrison; Su, Stephen; Tranberg, C. Elisabet; Wilson, Neil; Charman, Susan A.; Shackleford, David M.; Wilks, Andrew F.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4639 - 4642
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C
1.2: Amberlite IRC-50 / tetrahydrofuran
2.1: 73 percent / Amberlyst 15; Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Kruse, Chris G.; Bouw, Jan P.; Hes, Roelof van; Kuilen, Aalt van de; Hartog, Jack A. J. den
Heterocycles, 1987 , vol. 26, # 12 p. 3141 - 3151
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C
1.2: 77 percent / tetrahydrofuran / -78 - 20 °C
2.1: Amberlyst 15; H2O / acetone / 4 h / 20 °C
2.2: 81 percent / Et3N / CH2Cl2 / 2 h / 20 °C
3.1: sodium triacetoxyborohydride; AcOH / CH2Cl2; tetrahydrofuran / -78 - 20 °C
3.2: Amberlyst 15 / CH2Cl2; tetrahydrofuran / 1 h / 20 °C
3.3: 84 percent / Et3N / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
参考文献
SOLVAY PHARMACEUTICALS B.V.
Patent: WO2008/129054 A2, 2008 ;
Location in patent: Page/Page column 28-29 ;
