1,2,4,5-四氯苯合成路线 （共 206 条）
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) in diethyl ether
48 h; Heating;
参考文献
Eapen, Kalathil C.; Dua, Sujan S.; Tamborski, Christ
Journal of Organic Chemistry, 1984 , vol. 49, # 3 p. 478 - 482
反应条件
potassium hydroxide; tetra-(n-butyl)-phosphonium bromide in toluene
T=25°C; 2 h;
参考文献
Brunelle, D. J.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1309 - 1311
反应条件
potassium hydroxide; (Tricyclohexyl-n-dodecyl)phosphonium bromide in toluene
T=25°C; 2 h;
参考文献
Brunelle, D. J.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1309 - 1311
反应条件
1: methanol. NaOH / 160 °C
2: NaOH
3: HNO3 / 5 - 10 °C
4: acetic acid; aqueous ethanol; iron
5: chloroform; chlorine / Erwaermen des Reaktionsprodukts mit Schwefelsaeure
View Scheme
参考文献
Harrison; Peters; Rowe
Journal of the Chemical Society, 1943 , p. 235
反应条件
1: carbon dioxide With [Au(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)hydroxide]; potassium hydroxide in tetrahydrofuran
T=20°C; P=1125.11 Torr; 0.25 h;
2: 1,2,4,5-TeCB in tetrahydrofuran
T=20°C; P=1125.11 Torr; 12 h;
3: With hydrogenchloride in tetrahydrofuran; water
regioselective reaction;
参考文献
Boogaerts, Ine I. F.; Nolan, Steven P.
Journal of the American Chemical Society, 2010 , vol. 132, # 26 p. 8858 - 8859
反应条件
1: 1.) n-butyllithium / 1.) ether, hexane, -50 deg C, 85 min, 2.) -50 deg C to -35 deg C, 5.5 h
2: 85 percent / CHCl3, 50percent aq. NaOH, benzyltriethylammonium chloride / Ambient temperature
View Scheme
参考文献
Gribble, Gordon W.; Allen, Robert W.; LeHoullier, Craig S.; Eaton, Jefferson T.; Easton, N. Roy; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 1025 - 1026
反应条件
1: SO3/H2SO4
View Scheme
参考文献
Vejdelek; Protiva
Collection of Czechoslovak Chemical Communications, 1974 , vol. 39, # 6 p. 1596 - 1600
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=120°C; 1 h;
参考文献
Testaferri, L.; Tiecco, M.; Tingoli, M.; Chianelli, D.; Montanucci, M.
Tetrahedron, 1983 , vol. 39, # 1 p. 193 - 198
反应条件
sodium methylate
T=180°C; im Rohr;
参考文献
Holleman
Recueil des Travaux Chimiques des Pays-Bas, 1920 , vol. 39, p. 748
Recueil des Travaux Chimiques des Pays-Bas, 1921 , vol. 40, p. 318
参考文献
Harrison; Peters; Rowe
Journal of the Chemical Society, 1943 , p. 235
