反应条件
1.1: potassium acetate / benzene / 0.17 h / 18 - 25 °C / Inert atmosphere
1.2: 80 °C
1.3: 18 - 25 °C
2.1: N-iodo-succinimide / acetonitrile / 3 h / 60 °C / Inert atmosphere
3.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / isobutyramide / 0.75 h / 120 °C / Inert atmosphere
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; RAGHAVAN, Subharekha; STELMACH, John, E.; SMITH, Cameron, J.; LI, Hong; WHITEHEAD, Alan; WADDELL, Sherman, T.; CHEN, Yi-Heng; MIAO, Shouwu; ORNOSKI, Olga, A.; GARFUNKLE, Joie; LIAO, Xibin; CHANG, Jiang; HAN, Xiaoqing; GUO, Jian; GROEPER, Jonathan, A.; BROCKUNIER, Linda, L.; ROSAUER, Keith; PARMEE, Emma, R.
Patent: WO2011/149921 A1, 2011 ;