1-(5-氯吡啶-2-基)乙酮合成路线 (共 5 条)
反应条件
1: 2-Bromo-5-chloropyridine With sec.-butyllithium in diethyl ether; hexane T=-60°C; 2 h; 2: N,N-dimethyl acetamide in diethyl ether; hexane 3 h; 3: With hydrogenchloride; water in diethyl ether; hexane
参考文献
F2G LTD
Patent: WO2005/92304 A2, 2005 ;
Location in patent: Page/Page column 43 ;
反应条件
1: in tetrahydrofuran; diethyl ether T=-63 - 20°C; 2.25 h; 2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether 4 h; 3: With sodium hydrogencarbonate in tetrahydrofuran; diethyl ether pH=7;
参考文献
ASTRAZENECA AB
Patent: WO2008/39138 A1, 2008 ;
Location in patent: Page/Page column 28 ;
WO 2008/039138 A1
反应条件
1: in tetrahydrofuran T=0°C; 2 h; 2: With water in tetrahydrofuran
参考文献
US6642237 B1, ;
Page/Page column 224 ;
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl acetamide; water
反应条件
hydrogenchloride in diethyl ether; dichloromethane; water T=20°C;
参考文献
Gogsig, Thomas M.; Lindhardt, Anders T.; Dekhane, Mouloud; Grouleff, Julie; Skrydstrup, Troels
Chemistry - A European Journal, 2009 , vol. 15, # 24 p. 5950 - 5955