1: With sulfuric acid; nitric acid T=20°C; 5 h; 2: With sodium hydroxide pH=2 - 3;
参考文献
The Key Lab. Of Chemistry for Natural Products of Guizhou Province and Chinese Acad. of Sciences; Tianjin Institute of Pharmaceutical Research; 302 Hospital of PLA, China
Patent: US2009/247470 A1, 2009 ;
Location in patent: Page/Page column 12 ;
1: glycine With pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide; sodium methylate; nickel(II) nitrate hexahydrate in methanol 0.333333 h; Heating; 2: 1-bromomethyl-4-nitro-benzene With sodium hydroxide; (R)-NOBIN in dichloromethane T=20°C; 0.0666667 h; 3: With hydrogenchloride in methanol; water Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 10 p. 1948 - 1951
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=0°C; Resolution of racemate; Purification / work up;
