反应条件
1: 53 percent / KF, alumina / acetonitrile / 12 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, a) 0 deg C, 1 h, b) RT, 15 min, 2.) THF, hexane, a) from -78 deg C to RT, b) RT, 12 h
3: 31 percent / aq. HCl / tetrahydrofuran / 6 h / 60 °C
View Scheme
参考文献
Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang Jr., G. Phillip; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4800 - 4818
