4-(N-BOC-氨甲基)苯胺合成路线 （共 14 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=1810.07 Torr; 2 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 80, p. 101 - 111
反应条件
in tetrahydrofuran T=20°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 14 p. 3116 - 3126
Molecular Pharmacology, , vol. 62, # 4 p. 947 - 956
反应条件
1: 95 percent / DMAP; Et3N / CH2Cl2 2: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 24 p. 4389 - 4393
反应条件
1: 95 percent / DMAP; Et3N / CH2Cl2 2: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 24 p. 4389 - 4393
反应条件
1: 91 percent / Et3N / CH2Cl2 / 16 h / 0 °C 2: 31 percent / SnCl2*2H2O / ethanol / 1 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 19 p. 4189 - 4206
反应条件
triethylamine in 1,4-dioxane; water; ethyl acetate; Petroleum ether
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 35°C; 16 h; chemoselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 76, # 17 p. 7132 - 7140
反应条件
1: Et3N / toluene / 0 °C 2: 3.76 g / dimethylformamide / 20 °C 3: N2H4*H2O; TsOH*H2O / tetrahydrofuran / Heating 4: 600 mg / CH2Cl2 / 20 °C 5: 99 percent / H2 / 10 percent Pd/C contd. 50percent water / ethyl acetate / 20 °C / atmospheric pressure View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 5 p. 691 - 701
反应条件
1: 3.76 g / dimethylformamide / 20 °C 2: N2H4*H2O; TsOH*H2O / tetrahydrofuran / Heating 3: 600 mg / CH2Cl2 / 20 °C 4: 99 percent / H2 / 10 percent Pd/C contd. 50percent water / ethyl acetate / 20 °C / atmospheric pressure View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 5 p. 691 - 701
反应条件
1: N2H4*H2O; TsOH*H2O / tetrahydrofuran / Heating 2: 600 mg / CH2Cl2 / 20 °C 3: 99 percent / H2 / 10 percent Pd/C contd. 50percent water / ethyl acetate / 20 °C / atmospheric pressure View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 5 p. 691 - 701
