sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-benzyl-N,N,N-triethylammonium chloride in water; benzene 7 h;

1: 83 percent / butyllithium, I2 / hexane; hexamethylphosphoric acid triamide; tetrahydrofuran / -70 °C 2: 80 percent / (PPh3)4Pd, CuI, BnEt3N(+)*Cl(-), 2.5N NaOH / benzene; H2O / 7 h View Scheme