1-环丙基-6,7,8-三氟-4-氧代-1,4-二氢喹啉-3-羧酸合成路线 （共 21 条）
反应条件
sulfuric acid in water; acetic acid 1.5 h; Heating;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
hydrogenchloride; acetic anhydride in acetic acid; tert-butyl alcohol
参考文献
Warner-Lambert Company
Patent: US4771054 A1, 1988 ;
反应条件
in water; acetic acid
反应条件
1: 1.) Ac2O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght 2: t-BuOK / 2-methyl-propan-2-ol / 18 h / 50 °C 3: HCl / acetic acid / 2 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 991 - 1001
反应条件
1: t-BuOK / 2-methyl-propan-2-ol / 18 h / 50 °C 2: HCl / acetic acid / 2 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 991 - 1001
反应条件
1: tetrahydrofuran / 0.75 h / -78 °C 2: 1.) Ac2O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght 3: t-BuOK / 2-methyl-propan-2-ol / 18 h / 50 °C 4: HCl / acetic acid / 2 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 991 - 1001
反应条件
1: 95 percent / ethanol / 1 h / Ambient temperature 2: 78 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 86 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
1: p-toluenesulfonic acid / H2O / 5 h / Heating 2: acetic anhydride / 2 h / Heating 3: 95 percent / ethanol / 1 h / Ambient temperature 4: 78 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 5: 86 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
triethylamine in ethanol; water; acetonitrile
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: US5051509 A1, 1991 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile Heating;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
