4-(2-氧代-乙基)-哌嗪-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-78°C; Swern oxidation; 0.5 h; Inert atmosphere;
2: With triethylamine in dichloromethane
T=-78 - 20°C; Swern oxidation; 1.5 h; Inert atmosphere;
参考文献
Johnson, Mark; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5826 - 5840
反应条件
1: 90 percent / CHCl3 / 24 h / 20 °C
2: 50 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Dezi, Cristina; Brea, Jose; Alvarado, Mario; Ravina, Enrique; Masaguer, Christian F.; Loza, Maria Isabel; Sanz, Ferran; Pastor, Manuel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3242 - 3255
反应条件
1: 90 percent / CHCl3 / 24 h / 20 °C
2: 50 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Dezi, Cristina; Brea, Jose; Alvarado, Mario; Ravina, Enrique; Masaguer, Christian F.; Loza, Maria Isabel; Sanz, Ferran; Pastor, Manuel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3242 - 3255
反应条件
1.1: potassium carbonate / acetonitrile / 14 h / Inert atmosphere; Reflux
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 1.5 h / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
Johnson, Mark; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5826 - 5840
