7-氰基-3-溴-1H-吲唑合成路线 （共 8 条）
反应条件
sodium hydroxide; N-bromosuccinmide in N,N-dimethyl-formamide T=20°C; 5 h;
参考文献
Cottyn, Betty; Acher, Francine; Ramassamy, Booma; Alvey, Luke; Lepoivre, Michel; Frapart, Yves; Stuehr, Dennis; Mansuy, Daniel; Boucher, Jean-Luc; Vichard, Dominique
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5962 - 5973
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; zinc; tris(dibenzylideneacetone)dipalladium (0) in N,N-dimethyl acetamide 5 h; Heating;
参考文献
Cottyn, Betty; Vichard, Dominique; Terrier, Francois; Nioche, Pierre; Raman
Synlett, 2007 , # 8 p. 1203 - 1206
反应条件
1: 79 percent / NBS; NaOH / dimethylformamide / 48 h / 20 °C 2: 53 percent / dppf; Zn / Pd2(dba)3 / N,N-dimethyl-acetamide / 5 h / Heating View Scheme
参考文献
Synlett, , # 8 p. 1203 - 1206
反应条件
1: 98 percent / aq. NaNO2; glacial acetic acid / 0.33 h 2: 75 percent / NH4(+)HCOO(-); H2 / Pd/C / ethanol 3: 71 percent / HCl; H2SO4; NaNO2 / KI / 0 °C 4: 79 percent / NBS; NaOH / dimethylformamide / 48 h / 20 °C 5: 53 percent / dppf; Zn / Pd2(dba)3 / N,N-dimethyl-acetamide / 5 h / Heating View Scheme
参考文献
Synlett, , # 8 p. 1203 - 1206
反应条件
1: 71 percent / HCl; H2SO4; NaNO2 / KI / 0 °C 2: 79 percent / NBS; NaOH / dimethylformamide / 48 h / 20 °C 3: 53 percent / dppf; Zn / Pd2(dba)3 / N,N-dimethyl-acetamide / 5 h / Heating View Scheme
参考文献
Synlett, , # 8 p. 1203 - 1206
反应条件
1: 75 percent / NH4(+)HCOO(-); H2 / Pd/C / ethanol 2: 71 percent / HCl; H2SO4; NaNO2 / KI / 0 °C 3: 79 percent / NBS; NaOH / dimethylformamide / 48 h / 20 °C 4: 53 percent / dppf; Zn / Pd2(dba)3 / N,N-dimethyl-acetamide / 5 h / Heating View Scheme
参考文献
Synlett, , # 8 p. 1203 - 1206
反应条件
hydrogenchloride 48 h; Heating;
参考文献
Cottyn, Betty; Acher, Francine; Ramassamy, Booma; Alvey, Luke; Lepoivre, Michel; Frapart, Yves; Stuehr, Dennis; Mansuy, Daniel; Boucher, Jean-Luc; Vichard, Dominique
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5962 - 5973
反应条件
hydrogenchloride
48 h; Heating;
参考文献
Cottyn, Betty; Acher, Francine; Ramassamy, Booma; Alvey, Luke; Lepoivre, Michel; Frapart, Yves; Stuehr, Dennis; Mansuy, Daniel; Boucher, Jean-Luc; Vichard, Dominique
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5962 - 5973
