5-溴-3-氯- 2-吡啶甲腈合成路线 （共 2 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 1 h; 2: With copper in water 3: With sodium hydroxide in water
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/87488 A2, 2007 ;
Location in patent: Page/Page column 24 ;
反应条件
1.1: acetic acid; iron / 2 h / 80 °C 2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C 2.2: 1 h / Reflux View Scheme
参考文献
WO2011/51540 A1, ;
WO 2011/051540 A1
