2,4-二氨基-6-羟甲基蝶啶合成路线 （共 24 条）
反应条件
1: 2,4,5,6-tetraaminopyrimidine sulphate With BaCl2 in water T=100°C; 0.166667 h; 2: 1.3-dihydroxypropan-2-one With sodium acetate; dl-cysteine hydrochloride in water T=20°C; 24 h;
参考文献
BIORELIX, INC.; COISH, Philip, D., G.; WICKENS, Phil; DIXON, Brian; OSTERMAN, David; KHIRE, Uday, R.; NAVIA, Manuel; BERMAN, Judd; KAUR, Harpreet; WILSON, Jeffrey; UNDERWOOD, Dennis
Patent: WO2010/110907 A1, 2010 ;
Location in patent: Page/Page column 48-49 ;
WO 2010/110907 A1
反应条件
1: With sodium acetate; dl-cysteine hydrochloride in water T=20°C; 26 h; Heating / reflux; 2: With hydrogen bromide in ethanol T=70 - 75°C; 0.0833333 h; Heating / reflux;
参考文献
US2006/205729 A1, ;
Page/Page column 11 ;
反应条件
ammonium hydroxide in water Heating;
参考文献
Boyle, Peter H.; Pfleiderer, Wolfgang
Chemische Berichte, 1980 , vol. 113, # 4 p. 1514 - 1523
反应条件
ammonium hydroxide in methanol T=20°C; 24 h;
参考文献
Yao, Qizheng; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 1 - 12
反应条件
selenium(IV) oxide; sodium acetate in water
参考文献
Institutul Oncologic
Patent: US3989703 A1, 1976 ;
反应条件
sodium hydroxide in N,N-dimethyl-formamide 4 h; Ambient temperature;
参考文献
Matsuoka, Hiroharu; Kuroki, Toshio; Yano, Keiichi; Takeda, Yasuhisa
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 5 p. 363 - 368
反应条件
1: 2,4,5,6-tetraaminopyrimidine sulphate With BaCl2 in water T=90°C; 0.25 h; 2: L-cysteine monohydrochloride powder With ammonium hydroxide; oxygen; ammonium chloride in water T=5°C; 0.25 h; 3: With 1,3-dihydroxy-2-propanone-dimer; oxygen in water T=5 - 20°C; 48 h; Further stages.;
参考文献
Valiaeva; Bartley; Konno; Coward
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 5146 - 5154
反应条件
1: 78 percent / acetic acid / 3 h / Heating 2: 70 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C 3: 54 percent / aq. NH3 / methanol / 24 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 1 p. 1 - 12
反应条件
1: 70 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C 2: 54 percent / aq. NH3 / methanol / 24 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 1 p. 1 - 12
反应条件
1: 1.) Ph3P, 2.) NaOMe / 1.) DMF, 60 deg C, 3 h, 2.) DMF, 10 h 2: 34 percent / 2 h / 150 °C 3: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 30 min, 2.) CH2Cl2, MeOH, 0 deg C, 2 h 4: 63 percent / NaBH4 / CH2Cl2; propan-2-ol / 0.5 h / -10 °C 5: 77 percent / 1N aq. NaOH / dimethylformamide / 4 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 5 p. 363 - 368
