2-氨基-4-甲基嘧啶-5-硼酸频哪酯合成路线 （共 3 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=115°C; Suzuki Coupling; 18 h; Inert atmosphere;
参考文献
Genentech, Inc.; Heald, Robert Andrew; McLean, Neville James
Patent: US2014/65136 A1, 2014 ;
Location in patent: Paragraph 0198; 0199 ;
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=115°C; 18.25 h; Heating / reflux;
参考文献
WO2007/84786 A1, ;
Page/Page column 92-93 ;
WO 2007/084786 A1
反应条件
1: N-bromosuccinmide / chloroform / 18 h / Darkness 2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 8.33 h / Inert atmosphere View Scheme
参考文献
WO2012/82997 A1, ;
WO 2012/082997 A1
