2-(乙酰氧基甲基)-6-叠氮基四氢-2H-吡喃-3,4,5-三基三乙酸酯合成路线 （共 6 条）
反应条件
sodium azide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C; 16 h; Inert atmosphere;
参考文献
Capicciotti, Chantelle J.; Trant, John F.; Leclere, Mathieu; Ben, Robert N.
Bioconjugate Chemistry, 2011 , vol. 22, # 4 p. 605 - 616
反应条件
pyridine
T=20°C; 4 h; chemoselective reaction;
参考文献
McDonagh, Anthony W.; Murphy, Paul V.
Tetrahedron, 2014 , vol. 70, # 19 p. 3191 - 3196
反应条件
sodium azide in N,N-dimethyl-formamide
0.5 h; Sonication;
参考文献
Nagendra; Hemantha; Sureshbabu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 3 p. 397 - 407
反应条件
tetra-N-butylammonium azide in tetrahydrofuran
60 h; Reflux;
参考文献
Slamova, Kristyna; Marhol, Petr; Bezouska, Karel; Lindkvist, Lise; Hansen, Signe G.; Kren, Vladimir; Jensen, Henrik H.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4263 - 4265
反应条件
1: trimethylsilylazide; tin(IV) chloride / dichloromethane / 24 h / 0 - 20 °C
2: titanium tetrachloride / dichloromethane / 48.17 h / -15 - 0 °C
3: lithium iodide / ethyl acetate / 16 h / |Reflux
4: borane-THF / tetrahydrofuran / 0 - 20 °C
5: pyridine / 4 h / 20 °C
View Scheme
参考文献
McDonagh, Anthony W.; Murphy, Paul V.
Tetrahedron, 2014 , vol. 70, # 19 p. 3191 - 3196
反应条件
1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2: trimethylsilylazide; tin(IV) chloride / dichloromethane / 24 h / 0 - 20 °C
3: titanium tetrachloride / dichloromethane / 48.17 h / -15 - 0 °C
4: lithium iodide / ethyl acetate / 16 h / |Reflux
5: borane-THF / tetrahydrofuran / 0 - 20 °C
6: pyridine / 4 h / 20 °C
View Scheme
参考文献
McDonagh, Anthony W.; Murphy, Paul V.
Tetrahedron, 2014 , vol. 70, # 19 p. 3191 - 3196
