4-氨基-2,3,5,6-四氟苯甲酸合成路线 （共 13 条）
反应条件
sodium L-ascorbate; copper(II) sulfate in tetrahydrofuran T=70°C; 22 h;
参考文献
Xia, Yi; Li, Wei; Qu, Fanqi; Fan, Zhijin; Liu, Xiufeng; Berro, Charles; Rauzy, Evelyne; Peng, Ling
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 11 p. 1695 - 1701
反应条件
1: NH3 / methanol 2: aq. NaOH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 31, p. 821 - 824
参考文献
Journal of Organic Chemistry, , vol. 31, p. 821 - 824
反应条件
(i) nBuLi, (ii) /BRN= 1900390/, (iii) aq. HCl; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 31, p. 746 - 749
反应条件
tert.-butylnitrite; nitrogen in acetonitrile
参考文献
THE WELLCOME FOUNDATION LIMITED; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: EP279698 A3, 1990 ;
反应条件
in perchloric acid Electrochem. Process; at -1.5 V;
参考文献
Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84
反应条件
toluene-4-sulfonic acid; potassium iodide; sodium nitrite in N,N-dimethyl acetamide
参考文献
Qin, Luoheng; Sheridan, Christopher; Gao, Jianmin
Organic Letters, 2012 , vol. 14, # 2 p. 528 - 531
反应条件
1: 1.) NaNO2; 2.) NaN3 / 1.) TFA, 0 deg C, 0.5 h; 2.) Et2O, 1 h 2: 100 percent / PCl5 / diethyl ether / 0.17 h 3: 48 percent / AlCl3, TiCl4 / CH2Cl2 / 24 h / 25 °C 4: 80 percent / BF3*SMe2 / CH2Cl2 / 13 h / 25 °C / in the dark View Scheme
参考文献
Pinney, Kevin G.; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3125 - 3133
反应条件
1: With sodium nitrite in trifluoroacetic acid 1 h; 2: With sodium azide in diethyl ether 2 h; Further stages.;
参考文献
Cismas, Crina; Gimisis, Thanasis
Tetrahedron Letters, 2008 , vol. 49, # 8 p. 1336 - 1339
反应条件
1: 1.) NaNO2; 2.) NaN3 / 1.) TFA, 0 deg C, 0.5 h; 2.) Et2O, 1 h 2: 100 percent / PCl5 / diethyl ether / 0.17 h View Scheme
参考文献
Pinney, Kevin G.; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3125 - 3133
