1.1: pyridine 2.1: sodium hydride; water / N,N-dimethyl-formamide / 0 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / -20 °C 4.1: trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C 4.2: 20 °C 5.1: sodium methylate / methanol; dichloromethane / 0.5 h 6.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C 6.2: 24 h / 50 °C 7.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 8.1: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

1.1: sodium hydride; water / N,N-dimethyl-formamide / 0 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / -20 °C 3.1: trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C 3.2: 20 °C 4.1: sodium methylate / methanol; dichloromethane / 0.5 h 5.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C 5.2: 24 h / 50 °C 6.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 7.1: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / -20 °C 2.1: trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C 2.2: 20 °C 3.1: sodium methylate / methanol; dichloromethane / 0.5 h 4.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C 4.2: 24 h / 50 °C 5.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 6.1: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

1.1: trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C 1.2: 20 °C 2.1: sodium methylate / methanol; dichloromethane / 0.5 h 3.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C 3.2: 24 h / 50 °C 4.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 5.1: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

1.1: sodium methylate / methanol; dichloromethane / 0.5 h 2.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C 2.2: 24 h / 50 °C 3.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 4.1: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

1.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C 1.2: 24 h / 50 °C 2.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 3.1: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

1.1: potassium carbonate; tetrabutylammomium bromide / chloroform; water / 1 h / 50 °C 1.2: 24 h / 50 °C 2.1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 3.1: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

1: 10 Pd/C; acetic acid; hydrogen / ethyl acetate / 4 h / 760.05 Torr 2: sodium methylate / methanol; dichloromethane / 0.5 h View Scheme

sulfuric acid 2 h; Heating;