1-(三氟乙酰基)-2-吡咯烷酮合成路线 （共 3 条）
反应条件
potassium tert-butylate in tetrahydrofuran T=55°C; 1 h; Cooling with ice;
参考文献
Liu, Xu; Han, Zhaobin; Wang, Zheng; Ding, Kuiling
Angewandte Chemie - International Edition, 2014 , vol. 53, # 7 p. 1978 - 1982
Angew. Chem., 2014 , vol. 126, # 7 p. 2009 - 2013,5
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 3 h; Heating / reflux; 2: With hydrogen; palladium on carbon in ethyl acetate T=20°C; 3 h;
参考文献
NOVARTIS AG; XENON PHARMACEUTICALS, INC.
Patent: WO2008/36715 A1, 2008 ;
Location in patent: Page/Page column 49 ;
WO 2008/036715 A1
反应条件
in toluene
T=0 - 20°C; 1 h;
参考文献
NOVARTIS AG; XENON PHARMACEUTICALS, INC.
Patent: WO2008/36715 A1, 2008 ;
Location in patent: Page/Page column 48-49 ;
WO 2008/036715 A1
