4-氟-2,3-二羟基苯甲醛合成路线 （共 2 条）
反应条件
1: With boron tribromide in dichloromethane
T=-78 - 20°C;
2: With water in methanol; dichloromethane
T=-78 - 20°C; Product distribution / selectivity;
参考文献
ANACOR PHARMACEUTICALS, INC.; HERNANDEZ, Vincent, S.; DING, Charles; PLATTNER, Jacob, J.; ALLEY, Michael Richard, Kevin; ROCK, Fernando; ZHANG, Suoming; EASOM, Eric; LI, Xianfeng; ZHOU, Ding
Patent: WO2012/33858 A2, 2012 ;
Location in patent: Page/Page column 111 ;
反应条件
1.1: triethylamine; magnesium chloride / acetonitrile / 8 h / 80 °C
1.3: 0 - 20 °C
2.1: boron tribromide / dichloromethane / -78 - 20 °C
2.2: -78 - 20 °C
View Scheme
参考文献
ANACOR PHARMACEUTICALS, INC.; HERNANDEZ, Vincent, S.; DING, Charles; PLATTNER, Jacob, J.; ALLEY, Michael Richard, Kevin; ROCK, Fernando; ZHANG, Suoming; EASOM, Eric; LI, Xianfeng; ZHOU, Ding
Patent: WO2012/33858 A2, 2012 ;
