反式-4-叔丁基环己羧酸合成路线 （共 15 条）
反应条件
dipotassium peroxodisulfate; trifluoroacetic acid; palladium diacetate T=80°C;
参考文献
Chemistry Letters, , # 8 p. 1433 - 1436
反应条件
in tert-butylmethylether; 2,4-dimethylbutane; acetic acid T=25°C; Resolution of racemate; Purification / work up;
参考文献
WO2003/93270 A1, ;
Page/Page column 35-36 ;
WO 03/093270 A1
反应条件
sodium hydroxide; sodium hydride 1) 150 deg C, 2 h, 2) MeOH, 20 deg C, 10 min; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 7 p. 1436 - 1441
反应条件
1: 84 percent / phosphorus tribromide, pyridine / benzene / 12 h / 55 °C 2: 1.) Mg / 1.) ether, 2.) ether View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 661 - 668
反应条件
naphthalene; N,N,N',N,-tetramethylethylenediamine; potassium 1) THF, 25h room temperature 2) 21h 50 deg C; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3236 - 3245
反应条件
magnesium 1.) ether, 2.) ether; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 661 - 668
反应条件
in methanol; water T=23°C; relative rates; Pig Liver Esterase Hydrolysis; pH 7; var. methyl tert-butylcyclohexanecarboxylates;
参考文献
Journal of Organic Chemistry, , vol. 53, # 11 p. 2637 - 2639
反应条件
1: 56 percent / 85percent H2O2 2: 2 percent Chromat. / cyclohexane / 81 °C View Scheme
参考文献
Fossey, Jacques; Lefort, Daniel
Tetrahedron, 1980 , vol. 36, # 81 p. 1023 - 1036
反应条件
1: 56 percent / 85percent H2O2 2: 80 percent Chromat. / cyclohexane / 81 °C View Scheme
参考文献
Fossey, Jacques; Lefort, Daniel
Tetrahedron, 1980 , vol. 36, # 81 p. 1023 - 1036
反应条件
1: LiAlH4 / diethyl ether 2: pyridine View Scheme
参考文献
Ohloff, Guenther; Giersch, Wolfgang; Thommen, Walter; Willhalm, Bruno
Helvetica Chimica Acta, 1983 , vol. 66, # 5 p. 1343 - 1354
