2-(二氟甲基硫代)苯并噻唑合成路线 （共 8 条）
反应条件
1: 1-chloro-1,1-difluoro-methane With potassium hydroxide in ethylene glycol dimethyl ether; water
0.166667 h;
2: 2-mercaptobenzothiazole in ethylene glycol dimethyl ether; water
T=20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=95°C; 14 h; Inert atmosphere; Temperature; Overall yield = 91 percent;
参考文献
Mehta, Vaibhav P.; Greaney, Michael F.
Organic Letters, 2013 , vol. 15, # 19 p. 5036 - 5039
反应条件
potassium hydroxide in dichloromethane; water
T=0°C; 0.5 h;
参考文献
Li, Lingchun; Wang, Fei; Ni, Chuanfa; Hu, Jinbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12390 - 12394
Angew. Chem., 2013 , vol. 125, # 47 p. 12616 - 12620,5
反应条件
1: 2-mercaptobenzothiazole With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h; Inert atmosphere;
2: PhSO(NTS)CF2D in N,N-dimethyl-formamide
T=20 - 60°C;
参考文献
Zhang, Wei; Wang, Fei; Hu, Jinbo
Organic Letters, 2009 , vol. 11, # 10 p. 2109 - 2112
反应条件
potassium hydroxide in ethylene glycol dimethyl ether; water
T=20°C; 1 h;
参考文献
Prakash, G. K. Surya; Ni, Chuanfa; Wang, Fang; Hu, Jinbo; Olah, George A.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 11 p. 2559 - 2563
反应条件
tert.-butylhydroperoxide; trifluoroacetic acid in dichloromethane; water
T=23°C; 16 h; regioselective reaction;
参考文献
Fujiwara, Yuta; Dixon, Janice A.; Rodriguez, Rodrigo A.; Baxter, Ryan D.; Dixon, Darryl D.; Collins, Michael R.; Blackmond, Donna G.; Baran, Phil S.
Journal of the American Chemical Society, 2012 , vol. 134, # 3 p. 1494 - 1497
反应条件
potassium hydroxide in N,N-dimethyl-formamide
T=60 - 110°C; 0.166667 h;
参考文献
Petko; Yagupolskii
Journal of Fluorine Chemistry, 2001 , vol. 108, # 2 p. 211 - 214
反应条件
in para-xylene
T=90°C; 8 h; Sealed tubeInert atmosphere;
参考文献
Zheng, Jian; Lin, Jin-Hong; Cai, Ji; Xiao, Ji-Chang
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15261 - 15266
