(2s,4s)-N-cbz-2-羟甲基-4-氧-吡咯烷合成路线 （共 10 条）
反应条件
1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 20 °C 2: sodium dihydrogenphosphate; sodium chlorite; water / methyl-2-butene; tert-butyl alcohol / 1.5 h / 0 - 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr View Scheme
参考文献
Mereyala, Hari Babu; Pathuri, Gopal; Nagarapu, Lingaiah
Synthetic Communications, 2012 , vol. 42, # 9 p. 1278 - 1287
反应条件
1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 20 °C 2: sodium dihydrogenphosphate; sodium chlorite; water / methyl-2-butene; tert-butyl alcohol / 1.5 h / 0 - 20 °C View Scheme
参考文献
Mereyala, Hari Babu; Pathuri, Gopal; Nagarapu, Lingaiah
Synthetic Communications, 2012 , vol. 42, # 9 p. 1278 - 1287
反应条件
boron dimethyl-trifluoro sulphide in tetrahydrofuran
T=0 - 20°C; 2.5 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1961750 A1, 2008 ;
Location in patent: Page/Page column 108 ;
反应条件
sodium tetrahydroborate in methanol
T=0°C; 0.5 h; Reflux;
参考文献
Mereyala, Hari Babu; Pathuri, Gopal; Nagarapu, Lingaiah
Synthetic Communications, 2012 , vol. 42, # 9 p. 1278 - 1287
反应条件
lithium borohydride in tetrahydrofuran
参考文献
Ceulemans, G.; Aerschot, A. Van; Herdewijn, P.
Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, p. S234 - S237
反应条件
1: NaHCO3
2: methanol
3: LiBH4 / tetrahydrofuran
View Scheme
参考文献
Ceulemans, G.; Aerschot, A. Van; Herdewijn, P.
Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, p. S234 - S237
反应条件
1: NaHCO3
2: methanol
3: LiBH4 / tetrahydrofuran
View Scheme
参考文献
Ceulemans, G.; Aerschot, A. Van; Herdewijn, P.
Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, p. S234 - S237
反应条件
sodium tetrahydroborate in tetrahydrofuran; water
参考文献
Liu, Yi-Tsung; Wong, Jesse K.; Tao, Meng; Osterman, Rebecca; Sannigrahi, Mousumi; Girijavallabhan, Viyyoor M.; Saksena, Anil
Tetrahedron Letters, 2004 , vol. 45, # 32 p. 6097 - 6100
反应条件
1: sodium carbonate / dichloromethane; water / 8 h / 20 °C
2: hydrogenchloride; acetic acid / water / 0.5 h / Reflux
3: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Reflux
View Scheme
参考文献
Mereyala, Hari Babu; Pathuri, Gopal; Nagarapu, Lingaiah
Synthetic Communications, 2012 , vol. 42, # 9 p. 1278 - 1287
反应条件
1: hydrogenchloride; acetic acid / water / 0.5 h / Reflux
2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Reflux
View Scheme
参考文献
Mereyala, Hari Babu; Pathuri, Gopal; Nagarapu, Lingaiah
Synthetic Communications, 2012 , vol. 42, # 9 p. 1278 - 1287
