2-巯基-S-硫代苯甲酰乙酸合成路线 （共 56 条）
反应条件
1: 2: With water Acidic conditions;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 18 p. 5070 - 5076
反应条件
1: sodium hydroxide 2: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide; dichloromethane / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 18 p. 5070 - 5076
参考文献
Holmberg
Arkiv foer Kemi, 1947 , vol. 24A, # 3 p. 16
参考文献
Holmberg
Svedberg-Festschr. <Uppsala 1944> S. 299, 300
参考文献
Leon,N.H.; Asquith,R.S.
Tetrahedron, 1970 , vol. 26, p. 1719 - 1725
反应条件
in methanol T=20°C; 12 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19184 A1, 2005 ;
Location in patent: Page/Page column 24 ;
WO 2005/019184 A1
反应条件
thionyl chloride T=20°C; 4 h; Reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; Charrier, Jean-Damien; Durrant, Steven John; Knegtel, Ronald
Patent: US2013/115310 A1, 2013 ;
Location in patent: Paragraph 0240; 0241 ;
参考文献
Leon,N.H.; Asquith,R.S.
Tetrahedron, 1970 , vol. 26, p. 1719 - 1725
参考文献
Holmberg
Arkiv foer Kemi, 1947 , vol. 24A, # 3 p. 16
反应条件
1: 79 percent / alkali / H2O 2: 62 percent / conc. hydrochloric acid / ethanol View Scheme
参考文献
Askari, Syed H.; Moss, Stephen F.; Taylor, David R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 360 - 365
