3-氨基-5-苯基-1,2,4-三嗪合成路线 （共 27 条）
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / -25 °C 2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.25 h / 150 °C / Inert atmosphere View Scheme
参考文献
Congreve, Miles; Andrews, Stephen P.; Dore, Andrew S.; Hollenstein, Kaspar; Hurrell, Edward; Langmead, Christopher J.; Mason, Jonathan S.; Ng, Irene W.; Tehan, Benjamin; Zhukov, Andrei; Weir, Malcolm; Marshall, Fiona H.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1898 - 1903
反应条件
in methanol Heating;
参考文献
Jacobsen, Noel W.; Jonge, Ian de
Australian Journal of Chemistry, 1987 , vol. 40, # 12 p. 1979 - 1988
反应条件
ammonia; iron nitrate (III) in tetrahydrofuran
T=-33°C;
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
Location in patent: Page/Page column 97-98 ;
WO 2011/095625 A1
反应条件
KNH2; iron nitrate (III) in ammonia
T=-75°C; 0.0833333 h;
参考文献
Rykowski, A.; Plas, H. C. van der
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 881 - 885
反应条件
KNH2; iron nitrate (III) in ammonia
T=-33°C; 0.25 h; Further byproducts given;
参考文献
Rykowski, A.; Plas, H. C. van der
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 881 - 885
反应条件
KNH2; iron nitrate (III) in ammonia
T=-33°C; 0.25 h; Further byproducts given;
参考文献
Rykowski, A.; Plas, H. C. van der
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 881 - 885
反应条件
KNH2; iron nitrate (III) in ammonia
T=-33°C; 0.25 h; Further byproducts given;
参考文献
Rykowski, A.; Plas, H. C. van der
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 881 - 885
反应条件
ammonia
T=-33°C; 5 h;
参考文献
Rykowski, Andrzej
Polish Journal of Chemistry, 1983 , vol. 57, # 7-9 p. 1033 - 1036
反应条件
ammonia in ethanol
T=150°C; 24 h;
参考文献
Rykowski, Andrzej
Polish Journal of Chemistry, 1983 , vol. 57, # 7-9 p. 1033 - 1036
反应条件
1: 45 percent / phosphoryl chloride / 0.5 h / 120 °C
2: 64 percent / liquid ammonia / 30 h
View Scheme
参考文献
Rykowski, A.; Plas, H. C. van der
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 881 - 885
