1,2,3,4-四氢咔唑合成路线 （共 202 条）
参考文献
Ockenden; Schofield
Journal of the Chemical Society, 1953 , p. 612,616 1957 3175,3179
反应条件
1: 84 percent / KOH / dimethylsulfoxide / 2.5 h / Ambient temperature
2: 22 percent / POCl3 / 1 h / 120 °C
3: 2.) CrO3 in conc. H2SO4 (Jones reagent) / 1.) THF-hexane, -78 deg C, 30 min 2.) acetone, RT, 30 min
4: 70 percent / 1.5 h / 100 °C
5: 1.) NaBH4 2.) pyridine / 1.) ethanol, RT, 3 h 2.) RT, 2 d
View Scheme
参考文献
Yokoyama, Yuusaku; Okuyama, Naomi; Iwadate, Shinji; Momoi, Tokuko; Murakami, Yasuoki
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1319 - 1329
反应条件
sulfuric acid; potassium nitrate
T=-5 - -3°C;
参考文献
Perkin; Plant
Journal of the Chemical Society, 1921 , vol. 119, p. 1836
Journal of the Chemical Society, 1923 , vol. 123, p. 676
参考文献
Perkin; Plant
Journal of the Chemical Society, 1921 , vol. 119, p. 1836
Journal of the Chemical Society, 1923 , vol. 123, p. 676
反应条件
potassium hydroxide; cyclohexane; nitrogen
T=180°C; P=14710.2 Torr;
参考文献
Reppe et al.
Justus Liebigs Annalen der Chemie, 1956 , vol. 601, p. 81,104
反应条件
1: 1,2,3,4,10,11-hexahydrocarbazole With sodium hydride in tetrahydrofuran
T=20°C; 1 h;
2: methyl iodide in tetrahydrofuran
T=20°C; 0.25 h; Further stages.;
参考文献
Pitts; Harrison; Moody
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 955 - 977
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water; toluene
T=40 - 48°C; 2 h;
参考文献
YAMAMOTO CHEMICALS, INC.
Patent: WO2007/37196 A1, 2007 ;
Location in patent: Page/Page column 24-25 ;
反应条件
tetra(n-butyl)ammonium hydrogensulfate
参考文献
Acheson, R. Morrin; Choi, Michael C. K.; Letcher, Roy M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3141 - 3146
反应条件
ammonia; sodium; iron nitrate (III)
anschl. mit Methyljodid;
参考文献
Nakazaki; Isoe
Nippon Kagaku Zasshi, 1955 , vol. 76, p. 1159,1167
Chem.Abstr., 1957 , p. 17877
反应条件
acetic acid; platinum
Hydrogenation;
参考文献
Masamune et al.
J. Fac. Sci. Hokkaido Univ., 1957 , vol. <III> 5, p. 37,46
Full Text Show Details
Masamune et al.
Nippon Kagaku Zasshi, 1956 , vol. 77, p. 1017,1019
J. Fac. Sci. Hokkaido Univ., 1957 , vol. <III> 5, p. 37,39
