1-溴-2-(苯氧基甲基)苯合成路线 （共 20 条）
反应条件
tetrabutylammomium bromide; potassium acetate; palladium diacetate in N,N-dimethyl acetamide; water T=90°C; 6 h; SonicationInert atmosphere;
参考文献
Ultrasonics Sonochemistry, , vol. 19, # 2 p. 250 - 256
反应条件
1: 1-bromo-2-(phenoxymethyl)benzene With magnesium; ethylene dibromide in tetrahydrofuran T=20°C; 2.5 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 283 - 295
反应条件
ethyl bromide; diethyl ether; magnesium anschliessendes Behandeln mit CO2;
参考文献
Journal of the Chemical Society, , p. 2819,2824
反应条件
1: magnesium; diethyl ether; ethyl bromide / anschliessendes Behandeln mit CO2 2: LiAlH4; diethyl ether View Scheme
参考文献
Mann; Stewart
Journal of the Chemical Society, 1954 , p. 2819,2824
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium acetate in N,N-dimethyl acetamide T=160°C; 2 h;
参考文献
Tetrahedron, , vol. 40, # 10 p. 1919 - 1926
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -65 deg C to room temp., 6 h; Yield given. Multistep reaction;
参考文献
Kirmse, Wolfgang; Konrad, Wolfgang; Oezkir, Ismail S.
Tetrahedron, 1997 , vol. 53, # 29 p. 9935 - 9964
反应条件
potassium carbonate in acetone
T=50°C;
参考文献
Sun, Chang-Liang; Gu, Yi-Fan; Huang, Wei-Ping; Shi, Zhang-Jie
Chemical Communications, 2011 , vol. 47, # 35 p. 9813 - 9815
反应条件
1: phenol With sodium hydride in N,N-dimethyl-formamide
T=0°C; 1 h; Inert atmosphere;
2: 1-Bromo-2-(chloromethyl)benzene in N,N-dimethyl-formamide
3.16667 h;
参考文献
Majmudar, Jaimeen D.; Hodges-Loaiza, Heather B.; Hahne, Kalub; Donelson, James L.; Song, Jiao; Shrestha, Liza; Harrison, Marietta L.; Hrycyna, Christine A.; Gibbs, Richard A.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 283 - 295
反应条件
1: phenol With sodium hydride in DMF (N,N-dimethyl-formamide)
T=5 - 20°C;
2: 1-bromo-2-(bromomethyl)benzene in DMF (N,N-dimethyl-formamide)
T=5 - 20°C; 2 h;
参考文献
Despeyroux, Pierre; Frehel, Daniel; Schoentjes, Bruno; Van Dorsselaer, Viviane
Patent: US2006/52426 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
cesium fluoride in acetonitrile
T=20°C; 24 h;
参考文献
Liu, Zhijian; Larock, Richard C.
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3198 - 3209
