甲基6-(氯甲酰基)-2-吡啶羧酸酯合成路线 （共 12 条）
反应条件
methyllithium in tetrahydrofuran; diethyl ether 0.166667 h; Yield given;
参考文献
Young, Richard; Chang, C. K.
Journal of the American Chemical Society, 1985 , vol. 107, # 4 p. 898 - 909
反应条件
in toluene 4 h; Reflux;
参考文献
Zhu, Hengheng; He, Weiwei; Zhan, Chuanlang; Li, Xiao; Guan, Zisheng; Guo, Fengqi; Yao, Jiannian
Tetrahedron, 2011 , vol. 67, # 44 p. 8458 - 8464
反应条件
in diethyl ether; chloroform T=0°C; 0.5 h;
参考文献
Wei, Zhi-Liang; Li, Zu-Yi; Lin, Guo-Qiang
Tetrahedron, 1998 , vol. 54, # 43 p. 13059 - 13072
反应条件
1: sodium azide / tetrahydrofuran; water; N,N-dimethyl-formamide / 0.5 h / Cooling 2: toluene / 30 h / 120 °C 3: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 3 h / 50 °C View Scheme
参考文献
Zhao, Huaiqing; Ong, Wei Qiang; Fang, Xiao; Zhou, Feng; Hii, Meng Ni; Li, Sam Fong Yau; Su, Haibin; Zeng, Huaqiang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1172 - 1180
反应条件
thionyl chloride in benzene
T=50°C; 8 h;
参考文献
Young, Richard; Chang, C. K.
Journal of the American Chemical Society, 1985 , vol. 107, # 4 p. 898 - 909
反应条件
thionyl chloride in N,N-dimethyl-formamide
T=70°C; 4 h;
参考文献
Yang, Zhengfa; Tang, Ruiren; Zhang, Zhenfeng
Journal of Molecular Structure, 2012 , vol. 1030, p. 19 - 25
反应条件
1: 85 percent / KOH / methanol / 2 h / 0 °C
2: 22.0 g / oxalyl chloride; DMF / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Hull, Kenneth G.; Visnick, Mike; Tautz, William; Sheffron, Allen
Tetrahedron, 1997 , vol. 53, # 37 p. 12405 - 12414
反应条件
1: 83 percent / concentrated H2SO4 / 48 h / 70 °C
2: 85 percent / KOH / methanol / 2 h / 0 °C
3: 22.0 g / oxalyl chloride; DMF / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Hull, Kenneth G.; Visnick, Mike; Tautz, William; Sheffron, Allen
Tetrahedron, 1997 , vol. 53, # 37 p. 12405 - 12414
反应条件
thionyl chloride in tetrahydrofuran
T=20°C; Yield given;
参考文献
Kelly, T. Ross; Echavarren, Antonio; Chandrakumar, Nizal S.; Koeksal, Yetkin
Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2127 - 2130
反应条件
1: 1 h / 0 °C
2: KOH / methanol / 1 h
3: SOCl2 / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kelly, T. Ross; Echavarren, Antonio; Chandrakumar, Nizal S.; Koeksal, Yetkin
Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2127 - 2130
