2-氟-6-甲氧基苯甲腈合成路线 （共 19 条）
反应条件
in methanol T=0 - 20°C;
参考文献
BASF Aktiengesellschaft
Patent: WO2006/56433 A2, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
1: methanol With sodium hydride in tetrahydrofuran T=0°C; 0.166667 h; 2: 2,6-Difluorobenzonitrile in tetrahydrofuran T=20°C; 10 h;
参考文献
US2013/261139 A1, ;
Paragraph 0029-0030 ;
反应条件
acetic anhydride 4 h; Heating;
参考文献
Bridges, Alexander J.; Zhou, Hairong
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1163 - 1172
反应条件
1: 89 percent / NH2OH*HCl, NaHCO3 / H2O; ethanol / 2 h / 25 °C 2: 84 percent / Ac2O / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 4 p. 1163 - 1172
反应条件
1: 98 percent / KOH / H2O / 3 h / Heating 2: (COCl)2, DMF / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 15 p. 4520 - 4522
反应条件
in N,N-dimethyl acetamide T=140 - 142°C; 10 h;
参考文献
Hynes, John B.; Pathak, Alpana; Panos, Constantina H.; Okeke, Claudia C.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1173 - 1177
反应条件
1.1: tetrahydrofuran / 6 h / Reflux 1.2: 20 h / 75 °C 2.1: boron tribromide / dichloromethane / 1 h / -78 - 23 °C View Scheme
参考文献
Bryan, Marian C.; Biswas, Kaustav; Peterkin, Tanya A.N.; Rzasa, Robert M.; Arik, Leyla; Lehto, Sonya G.; Sun, Hong; Hsieh, Feng-Yin; Xu, Cen; Fremeau, Robert T.; Allen, Jennifer R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 619 - 622
反应条件
hydrazine hydrate in butan-1-ol 18 h; RefluxInert atmosphere;
参考文献
GLAXO GROUP LIMITED; BARTON, Nicholas, Paul; HOBBS, Heather; HODGSON, Simon, Teanby; LACROIX, Yannick, Maurice, Louis; PROCOPIOU, Panayiotis, Alexandrou
Patent: WO2012/25473 A1, 2012 ;
Location in patent: Page/Page column 32-33 ;
WO 2012/025473 A1
反应条件
dihydrogen peroxide; potassium carbonate in dimethyl sulfoxide T=0 - 25°C;
参考文献
Ni, Shuaishuai; Yuan, Yaxia; Huang, Jin; Mao, Xiaona; Lv, Maosheng; Zhu, Jin; Shen, Xu; Pei, Jianfeng; Lai, Luhua; Jiang, Hualiang; Li, Jian
Journal of Medicinal Chemistry, 2009 , vol. 52, # 17 p. 5295 - 5298
反应条件
potassium hydroxide in water 3 h; Heating;
参考文献
Horne, Stephen; Rodrigo, Russell
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4520 - 4522
