(3R,5S)-氟伐他汀钠盐合成路线 （共 15 条）
反应条件
1.1: triethylamine / dichloromethane / 2 h / 0 - 10 °C 2.1: potassium carbonate / acetonitrile / 70 °C 2.2: 15 h / 0 - 25 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C 4.1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C 5.1: sodium hydroxide; water / ethanol / 16 h / 20 - 25 °C View Scheme
参考文献
WO2012/2741 A2, ;
WO 2012/002741 A2
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C 2: hydrogenchloride; water / acetonitrile / 15 h / 40 °C 3: sodium hydroxide; water / ethanol / 16 h / 20 - 25 °C View Scheme
参考文献
WO2012/2741 A2, ;
WO 2012/002741 A2
反应条件
1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C 2: sodium hydroxide; water / ethanol / 16 h / 20 - 25 °C View Scheme
参考文献
WO2012/2741 A2, ;
WO 2012/002741 A2
反应条件
in toluene T=20°C; 168 h;
参考文献
US2005/261354 A1, ;
Page/Page column 53 ;
US 20050261354 A1
反应条件
sodium hydrogen sulphate in water; ethyl acetate
参考文献
US2005/261354 A1, ;
Page/Page column 53 ;
US 20050261354 A1
