(3R,5S)-氟伐他汀钠盐合成路线 （共 15 条）
反应条件
water; sodium hydroxide in ethanol T=20 - 25°C; 16 h;
参考文献
YUHAN CORPORATION; JU, Hyun; JOUNG, Sang-Sun; YI, Hyun-Jik; KHOO, Ja-Heouk; LIM, Jong-Chul; KIM, Jae-Gyu
Patent: WO2012/2741 A2, 2012 ;
Location in patent: Page/Page column 33-34 ;
WO 2012/002741 A2
反应条件
sodium hydroxide; water in methanol T=20°C; 2 h;
参考文献
WO2006/35286 A2, ;
Page/Page column 22-23 ;
反应条件
sodium hydroxide in ethanol T=25°C; 1.58333 h;
参考文献
Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron, 1997 , vol. 53, # 31 p. 10659 - 10670
反应条件
water; sodium hydroxide in methanol T=-40°C; 2 h;
参考文献
Zacharia, James T.; Tanaka, Takanori; Hayashi, Masahiko
Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7514 - 7518
反应条件
2: 1.) NaBH4, Et2BOMe, 2.) aq. NaHCO3, H2O2 / 1.) THF, MeOH, -78 deg C, 1.5 h, 2.) THF, MeOH, ethyl acetate, room temperature, 15 h 3: 90 percent / aq. NaOH / ethanol / 1.58 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 31 p. 10659 - 10670
反应条件
1: 1.) NaBH4, Et2BOMe, 2.) aq. NaHCO3, H2O2 / 1.) THF, MeOH, -78 deg C, 1.5 h, 2.) THF, MeOH, ethyl acetate, room temperature, 15 h 2: 90 percent / aq. NaOH / ethanol / 1.58 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 31 p. 10659 - 10670
反应条件
1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C 2.1: sodium hydroxide; water / methanol / 40 °C 2.2: pH 2 - 4 3.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / 0 - 30 °C 3.2: 20 - 25 °C 4.1: potassium carbonate / acetonitrile / 70 °C 4.2: 15 h / 0 - 25 °C 5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C 6.1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C 7.1: sodium hydroxide; water / ethanol / 16 h / 20 - 25 °C View Scheme
参考文献
WO2012/2741 A2, ;
WO 2012/002741 A2
反应条件
1.1: ammonium chloride / acetonitrile / 1 h / 0 - 30 °C 2.1: 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 0 - 25 °C 2.2: 10 h / 20 - 25 °C 3.1: triethylamine / dichloromethane / 2 h / 0 - 10 °C 4.1: potassium carbonate / acetonitrile / 70 °C 4.2: 15 h / 0 - 25 °C 5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C 6.1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C 7.1: sodium hydroxide; water / ethanol / 16 h / 20 - 25 °C View Scheme
参考文献
WO2012/2741 A2, ;
WO 2012/002741 A2
反应条件
1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / 0 - 30 °C 1.2: 20 - 25 °C 2.1: potassium carbonate / acetonitrile / 70 °C 2.2: 15 h / 0 - 25 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C 4.1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C 5.1: sodium hydroxide; water / ethanol / 16 h / 20 - 25 °C View Scheme
参考文献
WO2012/2741 A2, ;
WO 2012/002741 A2
反应条件
1.1: potassium carbonate / acetonitrile / 70 °C 1.2: 15 h / 0 - 25 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C 3.1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C 4.1: sodium hydroxide; water / ethanol / 16 h / 20 - 25 °C View Scheme
参考文献
WO2012/2741 A2, ;
WO 2012/002741 A2
