2-氰基-3-乙氧基丙烯酸乙酯合成路线 （共 100 条）
反应条件
1: 1-(2-morpholin-4-yl-2-oxoethyl)-4-methylpyridinium chloride With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide 2: ethyl(ethoxymethylene)cyanoacetate in N,N-dimethyl-formamide T=70°C; 24 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 59, p. 101 - 110
反应条件
hydrazine hydrate in ethanol T=20°C; 6 h;
参考文献
Deprez-Poulain, Rebecca; Cousaert, Nicolas; Toto, Patrick; Willand, Nicolas; Deprez, Benoit
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3867 - 3876
反应条件
in xylene 72 h; Heating;
参考文献
Massa; Mai; Artico; Corelli
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 6 p. 1805 - 1808
反应条件
1: hydrazine hydrate / ethanol / 6 h / 20 °C 2: trans-N,N'-dimethylcyclohexane-1,2-diamine; copper(l) iodide; potassium phosphate / 1,4-dioxane / 48 h / 110 °C / Inert atmosphere View Scheme
参考文献
Deprez-Poulain, Rebecca; Cousaert, Nicolas; Toto, Patrick; Willand, Nicolas; Deprez, Benoit
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3867 - 3876
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; water; toluene
参考文献
Ciba-Geigy Corporation
Patent: US5194628 A1, 1993 ;
参考文献
Popp,F.D.; Catala,A.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2738 - 2740
反应条件
acetic acid in water T=20°C; 12 h;
参考文献
Pandey, Garima; Bhowmik, Subhendu; Batra, Sanjay
Organic Letters, 2013 , vol. 15, # 19 p. 5044 - 5047
反应条件
in ethanol 4 h; Heating;
参考文献
Li, Jun-Fei; Zhu, You-Quan; Wang, Xin; Yang, Hua-Zheng
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 4 p. 749 - 755
反应条件
1: hydrazine hydrate / ethanol / 6 h / 20 °C 2: trans-N,N'-dimethylcyclohexane-1,2-diamine; copper(l) iodide; potassium phosphate / 1,4-dioxane / 48 h / 110 °C / Inert atmosphere View Scheme
参考文献
Deprez-Poulain, Rebecca; Cousaert, Nicolas; Toto, Patrick; Willand, Nicolas; Deprez, Benoit
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3867 - 3876
反应条件
acetic acid in water T=20°C; 12 h;
参考文献
Pandey, Garima; Bhowmik, Subhendu; Batra, Sanjay
Organic Letters, 2013 , vol. 15, # 19 p. 5044 - 5047
