2-氰基-3-乙氧基丙烯酸乙酯合成路线 （共 100 条）
反应条件
sodium ethanolate in ethanol
Heating;
参考文献
Kristen; Hamann; Kitzig
Pharmazie, 1976 , vol. 31, # 8 p. 536 - 540
反应条件
(i) NaOEt, (ii) NH4Cl; Multistep reaction;
参考文献
Kristen; Hamann; Kitzig
Pharmazie, 1976 , vol. 31, # 8 p. 536 - 540
反应条件
sodium ethanolate in ethanol
Heating;
参考文献
Kristen; Hamann; Kitzig
Pharmazie, 1976 , vol. 31, # 8 p. 536 - 540
参考文献
Gupte; Sunthankar
Journal of Organic Chemistry, 1959 , vol. 24, p. 1334
反应条件
ammonium chloride in N,N-dimethyl-formamide
参考文献
Bristol-Myers Company
Patent: US4082751 A1, 1978 ;
参考文献
de Bolllemont
Bulletin de la Societe Chimique de France, 1901 , vol. <3> 25, p. 41
反应条件
in ethanol
2 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/5284 A1, 2004 ;
Location in patent: Page 87-88 ;
WO 2004/005284 A1
反应条件
triethylamine in ethanol
T=25 - 78°C; 2.5 h;
参考文献
NOVARTIS AG
Patent: WO2008/107418 A1, 2008 ;
Location in patent: Page/Page column 21; 22 ;
WO 2008/107418 A1
反应条件
1: ethanol / 48 h
2: ethanol / 5 h / Heating
View Scheme
参考文献
Okamoto; Kurasawa; Takagi; et al.
Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 2 p. 243 - 247
反应条件
(i) NaOEt, (ii) aq. HCl; Multistep reaction;
参考文献
Kristen; Hamann; Kitzig
Pharmazie, 1976 , vol. 31, # 8 p. 536 - 540
