(E)-3-[3-(4-氟苯基)-1-异丙基吲哚-2-基]丙烯醛合成路线 （共 11 条）
反应条件
1: With trichlorophosphate in acetonitrile T=5 - 60°C; 4.5 - 7 h; 2: With water T=60°C; 1 h;
参考文献
Clariant Life Science Molecules (Italia) SpA
Patent: EP1477474 A1, 2004 ;
Location in patent: Page column 5 - 6 ;
反应条件
bis(trichloromethyl) carbonate; trichlorophosphate in chlorobenzene T=5 - 80°C;
参考文献
Clariant Life Science Molecules (Italia) SpA
Patent: EP1477474 A1, 2004 ;
Location in patent: Page column 6 ;
反应条件
1: 3-(N-methyl-N-phenylamino)-2-propenal With trichlorophosphate in acetonitrile T=-5 - 7°C; 0.916667 h; Inert atmosphere; 2: 3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole in acetonitrile 3 h; RefluxInert atmosphere;
参考文献
Zacharia, James T.; Tanaka, Takanori; Hayashi, Masahiko
Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7514 - 7518
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 57, # 11 p. 3250 - 3252
反应条件
1: acetoacetic acid tert-butyl ester With n-butyllithium; sodium hydride in tetrahydrofuran; hexane; paraffin oil T=0 - 25°C; Inert atmosphere; 2: 3-lt;3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-ylgt;-2(E)-propenal in tetrahydrofuran; hexane; paraffin oil T=0°C; Inert atmosphere;
参考文献
Fuenfschilling, Peter C.; Hoehn, Pascale; Mutz, Jean-Paul
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 13 - 18
反应条件
1: acetoacetic acid tert-butyl ester With n-butyllithium; sodium hydride in tetrahydrofuran; hexane; paraffin oil T=0 - 25°C; Inert atmosphere; 2: 3-lt;3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-ylgt;-2(E)-propenal in tetrahydrofuran; hexane; paraffin oil T=0°C; Inert atmosphere; 3: With water T=0°C; Temperature;
参考文献
Fuenfschilling, Peter C.; Hoehn, Pascale; Mutz, Jean-Paul
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 13 - 18
反应条件
2: 1.) NaBH4, Et2BOMe, 2.) aq. NaHCO3, H2O2 / 1.) THF, MeOH, -78 deg C, 1.5 h, 2.) THF, MeOH, ethyl acetate, room temperature, 15 h 3: 90 percent / aq. NaOH / ethanol / 1.58 h / 25 °C View Scheme
参考文献
Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron, 1997 , vol. 53, # 31 p. 10659 - 10670
反应条件
Yield given. Multistep reaction;
参考文献
Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron, 1997 , vol. 53, # 31 p. 10659 - 10670
反应条件
2: 1.) NaBH4, Et2BOMe, 2.) aq. NaHCO3, H2O2 / 1.) THF, MeOH, -78 deg C, 1.5 h, 2.) THF, MeOH, ethyl acetate, room temperature, 15 h View Scheme
参考文献
Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron, 1997 , vol. 53, # 31 p. 10659 - 10670
反应条件
Yield given. Multistep reaction;
参考文献
Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron, 1997 , vol. 53, # 31 p. 10659 - 10670
