4-(甲氧基甲基)苯甲醛合成路线 （共 28 条）
反应条件
1.1: 73 percent / p-toluenesulfonic acid / toluene / Heating 2.1: Li; naphthalene / tetrahydrofuran / 4.5 h / -40 °C 2.2: H2O / tetrahydrofuran / 0.5 h View Scheme
参考文献
Azzena, Ugo; Dettori, Giovanna; Pisano, Luisa; Siotto, Immacolata
Tetrahedron, 2005 , vol. 61, # 13 p. 3177 - 3182
反应条件
1.1: 73 percent / p-toluenesulfonic acid / toluene / Heating 2.1: Li; naphthalene / tetrahydrofuran / 6 h / -50 °C 2.2: tetrahydrofuran / 0.5 h 3.1: H2SO4 / tetrahydrofuran; H2O / 1 h / 20 °C View Scheme
参考文献
Azzena, Ugo; Dettori, Giovanna; Pisano, Luisa; Siotto, Immacolata
Tetrahedron, 2005 , vol. 61, # 13 p. 3177 - 3182
反应条件
1: p-(hydroxymethyl)benzaldehyde With sodium hydride in tetrahydrofuran
T=20°C; 0.25 h;
2: methyl iodide in tetrahydrofuran
T=20°C; 16 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/136756 A1, 2008 ;
Location in patent: Page/Page column 126 ;
WO 2008/136756 A1
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane; water
Ambient temperature;
参考文献
Wang, Wuyi; Li, Tiechao; Attardo, Giorgio
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6598 - 6602
反应条件
1: 1-bromo-4-(methoxymethyl)benzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.25 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=20°C; 0.5 h;
参考文献
Stuhr-Hansen, Nicolai; Sorensen, Jakob Kryger; Moth-Poulsen, Kasper; Christensen, Jorn Bolstad; Bjornholm, Thomas; Nielsen, Mogens Brondsted
Tetrahedron, 2005 , vol. 61, # 52 p. 12288 - 12295
反应条件
nitric acid in dichloromethane
T=20°C; 1 h;
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
反应条件
2-hydroxy-1,3-isoindolinedione; nitrogen(II) oxide in acetonitrile
T=60°C; 10 h;
参考文献
Eikawa, Masahiro; Sakaguchi, Satoshi; Ishii, Yasutaka
Journal of Organic Chemistry, 1999 , vol. 64, # 13 p. 4676 - 4679
反应条件
polystyrene-supported iodosylbenzene in dichloromethane
6 h;
参考文献
Chen, Jiang-Min; Zeng, Xiao-Mei; Middleton, Kyle; Yusubov, Mekhman S.; Zhdankin, Viktor V.
Synlett, 2011 , # 11 p. 1613 - 1617
反应条件
1: methanol / Ambient temperature
2: 96 percent / DDQ / CH2Cl2; H2O / Ambient temperature
View Scheme
参考文献
Wang, Wuyi; Li, Tiechao; Attardo, Giorgio
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6598 - 6602
反应条件
1: 94 percent / LiAlH4 / diethyl ether
2: 79 percent / HNO3 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
