4,4-二乙氧基-2-丁炔酸甲酯合成路线 （共 4 条）
反应条件
1: HCO2H 2: (R)-BINOL-Ti, 4 Angstroem molecular sieves / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Mikami, Koichi; Yoshida, Akihiro; Matsumoto, Youichi
Tetrahedron Letters, 1996 , vol. 37, # 47 p. 8515 - 8518
反应条件
methyllithium in tetrahydrofuran
T=-78°C;
参考文献
Freskos, John; Cynkowski, Tadeusz; Swenton, John S.
Journal of the Chemical Society, Chemical Communications, 1984 , # 13 p. 819 - 820
反应条件
1: propargyladehyde di-ethyl acetal With n-butyllithium in diethylene glycol dimethyl ether
T=-30°C; 6 h;
2: methyl chloroformate in diethylene glycol dimethyl ether
T=-30 - 20°C;
参考文献
AMGEN INC.
Patent: WO2006/79099 A2, 2006 ;
Location in patent: Page/Page column 73-74 ;
反应条件
in toluene
T=165°C; 6 h;
参考文献
Haack, Torsten; Kurtkaya, Serdar; Snyder, James P.; Georg, Gunda I.
Organic Letters, 2003 , vol. 5, # 26 p. 5019 - 5022
