2-(4-甲基苯基)丙酸合成路线 （共 38 条）
反应条件
water; bis-triphenylphosphine-palladium(II) chloride in butanone T=115°C; P=40504.1 Torr; 0.38 h;
参考文献
Seayad; Jayasree; Chaudhari
Organic Letters, 1999 , vol. 1, # 3 p. 459 - 461
反应条件
sodium hydroxide Yield given;
参考文献
Synthesis, , # 6 p. 444 - 445
反应条件
phosphorus; hydrogen iodide in water T=120°C; 24 h;
参考文献
Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello
Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021
反应条件
sodium hydroxide in methanol 2 h; Heating;
参考文献
Matsumoto; Ishida; Yoshida; Terao; Takeda; Asakawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 7 p. 1721 - 1726
反应条件
hydrogenchloride; oxygen; 6-hydroxy-6-oxo-2,5,7,10-tetraoxa-6-phospha-tricyclo[6.3.0.04,11]undecane; copper dichloride; palladium dichloride in tetrahydrofuran; water T=20°C; 12 h; Title compound not separated from byproducts;
参考文献
Heterocycles, , vol. 63, # 12 p. 2797 - 2803
反应条件
1: (4-methylphenyl)acetic acid With N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium in tetrahydrofuran; hexane T=0 - 20°C; Metallation; 2: methyl iodide in tetrahydrofuran; hexane T=20°C; Methylation;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 8 p. 1767 - 1775
反应条件
carbon monoxide; palladium on activated charcoal; 1,4-di(diphenylphosphino)-butane in ethylene glycol dimethyl ether T=150°C; P=5168 Torr; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 58, # 17 p. 4739 - 4741
反应条件
carbon monoxide; palladium on activated charcoal; 1,4-di(diphenylphosphino)-butane in ethylene glycol dimethyl ether T=150°C; P=30400 Torr; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 58, # 17 p. 4739 - 4741
反应条件
triethylamine; mercury in tetrahydrofuran
反应条件
potassium hydroxide; polyethylene glycol (PEG-400); potassium cyanide; nickel cyanide; cobalt(II) chloride in toluene T=90°C; P=760 Torr; 24 h; other alkynes; regioselectivity;
参考文献
Tetrahedron Letters, , vol. 32, # 15 p. 1769 - 1770
