3,4-二甲基-1H-吡咯-2-羧酸乙酯合成路线 （共 34 条）
反应条件
1: 83 percent / BF3*Et2O / CH2Cl2 / 24 h / Ambient temperature 2: 60 percent / NaOH / ethanol; H2O / 5 h / 70 °C View Scheme
参考文献
Banfi, Stefano; Manfredi, Amedea; Pozz, Gianluca; Quici, Silvio; Trebicka, Artan
Gazzetta Chimica Italiana, 1996 , vol. 126, # 3 p. 179 - 185
反应条件
1.1: sodium hydroxide / ethylene glycol / 1 h / |Reflux 2.1: trichlorophosphate / 0 °C / |Inert atmosphere 2.2: 10 h / 20 °C / |Inert atmosphere 2.3: 1 h / 20 °C 3.1: 1,3-dibromo-5,5-dimethyl-hydantoin / tetrahydrofuran / 5 h / -78 - 20 °C / |Inert atmosphere View Scheme
参考文献
Kancharla, Papireddy; Reynolds, Kevin A.
Tetrahedron, 2013 , vol. 69, # 39 p. 8375 - 8385
反应条件
1: 96 percent / NaOH, then H+ / ethanol / 2.) reflux 2: 1.) POCl3; 2.) NaOAc / 1.) 1,2-dichloroethane, reflux; 2.) H2O, reflux View Scheme
参考文献
Chen, Qingqi; Wang, Tianyu; Zhang, Yi; Wang, Qiuan; Ma, Jinshi
Synthetic Communications, 2002 , vol. 32, # 7 p. 1031 - 1040
反应条件
sodium hydroxide in ethanol; water 16 h; Heating;
参考文献
Roth, Steven D.; Shkindel, Tetyana; Lightner, David A.
Tetrahedron, 2007 , vol. 63, # 45 p. 11030 - 11039
反应条件
sodium hydroxide; hydrogen cation in ethanol 2.) reflux;
参考文献
Nogales, Daniel F.; Timothy Anstine; Lightner, David A.
Tetrahedron, 1994 , vol. 50, # 29 p. 8579 - 8596
反应条件
potassium carbonate in tetrahydrofuran; ethanol
T=20°C; 48 h;
参考文献
Roth, Steven D.; Shkindel, Tetyana; Lightner, David A.
Tetrahedron, 2007 , vol. 63, # 45 p. 11030 - 11039
反应条件
ethylene glycol; toluene-4-sulfonic acid in benzene
0.0833333 h; Heating;
参考文献
Moon, M. W.; Wade, R. A.
Journal of Organic Chemistry, 1984 , vol. 49, # 15 p. 2663 - 2669
反应条件
sodium acetate; acetic acid; zinc
T=95 - 110°C; 0.75 h;
参考文献
Helms, Anna; Heiler, David; McLendon, George
Journal of the American Chemical Society, 1992 , vol. 114, # 15 p. 6227 - 6238
反应条件
sodium acetate; acetic acid; zinc
T=100°C;
参考文献
Kleinspehn
Journal of the American Chemical Society, 1955 , vol. 77, p. 1546
反应条件
zinc in water; acetic acid
T=90 - 100°C; 0.5 h;
参考文献
Chen, Qingqi; Wang, Tianyu; Zhang, Yi; Wang, Qiuan; Ma, Jinshi
Synthetic Communications, 2002 , vol. 32, # 7 p. 1031 - 1040
