5-溴-2-氟苯甲醛合成路线

参考文献

UNIVERSITY HEALTH NETWORK
Patent: WO2009/79767 A1, 2009 ;
Location in patent: Page/Page column 84 ;
WO 2009/079767 A1

参考文献

DiMauro, Erin F.; Newcomb, John; Nunes, Joseph J.; Bemis, Jean E.; Boucher, Christina; Buchanan, John L.; Buckner, William H.; Cee, Victor J.; Chai, Lilly; Deak, Holly L.; Epstein, Linda F.; Faust, Ted; Gallant, Paul; Geuns-Meyer, Stephanie D.; Gore, Anu; Gu, Yan; Henkle, Brad; Hodous, Brian L.; Hsieh, Faye; Huang, Xin; Kim, Joseph L.; Lee, Josie H.; Martin, Matthew W.; Masse, Craig E.; McGowan, David C.; Metz, Daniela; Mohn, Deanna; Morgenstern, Kurt A.; Oliveira-Dos-Santos, Antonio; Patel, Vinod F.; Powers, David; Rose, Paul E.; Schneider, Stephen; Tomlinson, Susan A.; Tudor, Yan-Yan; Turci, Susan M.; Welcher, Andrew A.; White, Ryan D.; Zhao, Huilin; Zhu, Li; Zhu, Xiaotian
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5671 - 5686

93777-26-55-溴-2-氟苯甲醛

864774-65-21-(5-溴-2-氟苯基)-1-丙酮

参考文献

Freeman-Cook, Kevin D.; Amor, Paul; Bader, Scott; Buzon, Leanne M.; Coffey, Steven B.; Corbett, Jeffrey W.; Dirico, Kenneth J.; Doran, Shawn D.; Elliott, Richard L.; Esler, William; Guzman-Perez, Angel; Henegar, Kevin E.; Houser, Janet A.; Jones, Christopher S.; Limberakis, Chris; Loomis, Katherine; McPherson, Kirk; Murdande, Sharad; Nelson, Kendra L.; Phillion, Dennis; Pierce, Betsy S.; Song, Wei; Sugarman, Eliot; Tapley, Susan; Tu, Meihua; Zhao, Zhengrong
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 935 - 942

93777-26-55-溴-2-氟苯甲醛

885223-58-53-甲基-1H-吲唑-5-羧酸

参考文献

Freeman-Cook, Kevin D.; Amor, Paul; Bader, Scott; Buzon, Leanne M.; Coffey, Steven B.; Corbett, Jeffrey W.; Dirico, Kenneth J.; Doran, Shawn D.; Elliott, Richard L.; Esler, William; Guzman-Perez, Angel; Henegar, Kevin E.; Houser, Janet A.; Jones, Christopher S.; Limberakis, Chris; Loomis, Katherine; McPherson, Kirk; Murdande, Sharad; Nelson, Kendra L.; Phillion, Dennis; Pierce, Betsy S.; Song, Wei; Sugarman, Eliot; Tapley, Susan; Tu, Meihua; Zhao, Zhengrong
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 935 - 942

93777-26-55-溴-2-氟苯甲醛

872607-89-11-甲基-1H-吲唑-5-羧醛

参考文献

NOVARTIS AG; DAI, Miao; FU, Xingnian; HE, Feng; JIANG, Lei; LI, Yue; LIANG, Fang; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YAN, Xiaoxia; YU, Zhengtian; ZHANG, Ji, Yue
Patent: WO2011/20861 A1, 2011 ;

93777-26-55-溴-2-氟苯甲醛

864774-67-45-溴-3-乙基-1H-吲唑

参考文献

Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 6832 - 6846

2365-48-2巯基乙酸甲酯+

93777-26-55-溴-2-氟苯甲醛

7312-11-05-溴-1-苯并噻吩-2-羧酸甲酯

参考文献

BAYER HEALTHCARE AG
Patent: WO2003/104227 A1, 2003 ;
Location in patent: Page 51 ;

107-21-1乙二醇+

93777-26-55-溴-2-氟苯甲醛

679840-30-31,1-二乙氧乙烷

参考文献

JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/2820 A2, 2008 ;
Location in patent: Page/Page column 62 ;
WO 2008/002820 A2

93777-26-55-溴-2-氟苯甲醛

761423-87-4Ipragliflozin; (1S)-1,5-脱水-1-C-[3-[(1-苯并噻吩-2-基)甲基]-4-氟苯基]-D-葡糖醇

参考文献

Imamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3263 - 3279

110-85-0哌嗪+

24424-99-5二碳酸二叔丁酯+

93777-26-55-溴-2-氟苯甲醛

628326-05-61-BOC-4-(4-溴-2-甲酰苯基)哌啶

参考文献

Tan, John Q.; Kim, Ronald M.; Mirc, John W.
Patent: US2013/210798 A1, 2013 ;
Location in patent: Paragraph 0255; 0256 ;