2-氰基-4’-甲基联苯合成路线 （共 11 条）
反应条件
sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; tris-(o-tolyl)phosphine in water; acetonitrile 2 h; Heating / reflux;
参考文献
Shaber, Steven Howard; Yap, Maurice Chee Hoong; Meyer, Kevin Gerald; Niyaz, Noormohamed Mohamed; Rieder, Brent Jeffrey; Sullenberger, Michael Thomas; Erickson, William Randal; Smith, Frisby Davis
Patent: US2006/252755 A1, 2006 ;
Location in patent: Page/Page column 34 ;
Title/Abstract Full Text Show Details
Meyer, Kevin Gerald; Shaber, Steven Howard; Yap, Maurice Chee Hoong; Niyaz, Noormohamed Mohamed; Rieder, Brent Jeffrey; Sullenberger, Michael Thomas; Erickson, William Randal; Smith, Frisby Davis
Patent: US2006/252755 A1, 2006 ;
Location in patent: Page/Page column 34 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=95°C; 48 h;
参考文献
THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER
Patent: WO2009/26248 A2, 2009 ;
Location in patent: Page/Page column 53; 54 ;
反应条件
3-chloroprop-1-ene; trifluoroacetic acid; cobalt(II) dibromide; zinc in acetonitrile T=20°C; Barbier type reductive cross-coupling;
参考文献
Amatore, Muriel; Gosmini, Corinne
Chemical Communications, 2008 , # 40 p. 5019 - 5021
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=95°C; 48 h;
参考文献
Xue, Zhi Zhao; Semenova, Elena A.; Vu, B. Christie; Maddali, Kasthuraiah; Marchand, Christophe; Hughes, Stephen H.; Pommier, Yves; Burke Jr., Terrence R.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 2 p. 251 - 259
反应条件
para-dicyanobenzene in methanol; acetonitrile T=10°C; Irradiation; Yield given;
参考文献
Canadian Journal of Chemistry, , vol. 73, # 3 p. 307 - 318
反应条件
aluminium trichloride 10 h; Heating;
参考文献
Arnold, Donald R.; Du, Xinyao; Chen, Jing
Canadian Journal of Chemistry, 1995 , vol. 73, # 3 p. 307 - 318
反应条件
1: diethyl ether; benzene / Ambient temperature 2: thionyl chloride / CH2Cl2 / 6 h / Heating 3: 38 percent / 1,4-dicyanobenzene / acetonitrile / 10 °C / Irradiation 4: 1,4-dicyanobenzene / methanol; acetonitrile / 10 °C / Irradiation View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 73, # 3 p. 307 - 318
反应条件
1: 38 percent / 1,4-dicyanobenzene / acetonitrile / 10 °C / Irradiation 2: 1,4-dicyanobenzene / methanol; acetonitrile / 10 °C / Irradiation View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 73, # 3 p. 307 - 318
反应条件
1: thionyl chloride / CH2Cl2 / 6 h / Heating 2: 38 percent / 1,4-dicyanobenzene / acetonitrile / 10 °C / Irradiation 3: 1,4-dicyanobenzene / methanol; acetonitrile / 10 °C / Irradiation View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 73, # 3 p. 307 - 318
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
4 h; Heating;
参考文献
THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER
Patent: WO2009/26248 A2, 2009 ;
Location in patent: Page/Page column 54 ;
