8-溴-3-甲基-3,7-二氢-嘌呤-2,6-二酮合成路线 （共 6 条）
反应条件
bromine; sodium acetate in acetic acid
反应条件
KBrO3; hydrogen bromide in acetic acid T=80 - 95°C; 12 h;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 20, # 8 p. 924 - 927
Khimiya Geterotsiklicheskikh Soedinenii, , # 8 p. 1129 - 1132
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=80°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 26 p. 6450 - 6453
反应条件
1: 8-Bromo-3-methyl-3,7-dihydropurine-2,6-dione With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=-25 - 70°C; Inert atmosphere; 2: 3',4'-dihydroxy-2-chloroacetophenone in N,N-dimethyl-formamide T=70°C; 5 h; Inert atmosphere;
参考文献
Lafleur, Karine; Huang, Danzhi; Zhou, Ting; Caflisch, Amedeo; Nevado, Cristina
Journal of Medicinal Chemistry, 2009 , vol. 52, # 20 p. 6433 - 6446
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 6 h;
参考文献
PROTEOTECH INC; ESPOSITO, Luke; HANSON, Kelsey; YADON, Marisa, C.; LAKE, Thomas; KUMAR, Anil; SNOW, Alan, D.; CUMMINGS, Joel
Patent: WO2013/62762 A1, 2013 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
Cell Therapeutics, Inc.
Patent: US6878715 B1, 2005 ;
