(S)-1,4-二氮杂双环[4.3.0]壬烷合成路线 （共 7 条）
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol 1 h;
参考文献
ASKA Pharmaceutical Co., Ltd.
Patent: EP1724267 A1, 2006 ;
Location in patent: Page/Page column 130 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 27 h; Heating;
参考文献
Nazarova, L. S.; Rozonov, Yu. B.; Likhosherstov, A. M.; Morozova, T. V.; Skoldinov, A. P.; et al.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 12 p. 1445 - 1448
反应条件
lithium aluminium tetrahydride in diethyl ether 10 h; Heating;
参考文献
Nazarova, L. S.; Rozonov, Yu. B.; Likhosherstov, A. M.; Morozova, T. V.; Skoldinov, A. P.; et al.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 58 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, HOBT monohydrate, Et3N / 24 h / Ambient temperature 2: 100 percent / 1 h / Ambient temperature 3: 65 percent / Et3N / methanol / Heating 4: LiAlH4 / tetrahydrofuran / 0.17 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 16 p. 2311 - 2320
反应条件
1: 92.5 percent / SOCl2 2: 15.7 percent / ethanol / 36 h 3: 55 percent / LiAlH4 / diethyl ether / 10 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 15.7 percent / ethanol / 36 h 2: 55 percent / LiAlH4 / diethyl ether / 10 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 78.2 percent / NH3 / ethanol / Ambient temperature 2: 68.9 percent / LiAlH4 / tetrahydrofuran / 27 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
