2-甲基吡咯-3-甲酸乙酯合成路线 （共 28 条）
反应条件
ammonia in tetrahydrofuran
参考文献
Cambie, R.C.; Moratti, S.C.; Rutledge, P.S.; Woodgate, P.D.
Synthetic Communications, 1990 , vol. 20, # 13 p. 1923 - 1929
反应条件
1: vinyl acetate With bromine T=0°C; 1 h; 2: ethyl acetoacetate With ammonia in water T=20°C; 1.5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2007/60623 A1, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); 2-Bromo-1,3,5-trimethyl-benzene; potassium carbonate in N,N-dimethyl-formamide T=150°C; 1 h;
参考文献
Aoyagi, Yutaka; Mizusaki, Toshihiko; Shishikura, Masahiro; Komine, Takashi; Yoshinaga, Tokuji; Inaba, Haruko; Ohta, Akihiro; Takeya, Koichi
Tetrahedron, 2006 , vol. 62, # 36 p. 8533 - 8538
反应条件
1: vinyl acetate With bromine T=0°C; 1 h; 2: ethyl acetoacetate With ammonia in water T=20°C; 0.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/36024 A1, 2006 ;
Location in patent: Page/Page column 145-146; 288 ;
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=-20°C; 1 h;
参考文献
Alberola, Angel; Ortega, Alfonso Gonzalez; Sadaba, M. Luisa; Sanudo, Carmen
Tetrahedron, 1999 , vol. 55, # 21 p. 6555 - 6566
反应条件
trimethylsilyl trifluoromethanesulfonate T=-40°C; 10 h;
参考文献
Organic Letters, , vol. 5, # 26 p. 5099 - 5101
反应条件
sodium hydroxide in methanol 0.25 h;
参考文献
Flitsch, Wilhelm; Pandl, Klaus; Russkamp, Petra
Liebigs Annalen der Chemie, 1983 , # 4 p. 529 - 534
反应条件
in dimethyl sulfoxide T=150°C; 24 h;
参考文献
Bellur, Esen; Langer, Peter
Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2151 - 2154
反应条件
[Au(IPr)(acetonitrile)]BF4 T=20°C; 14 h; Inert atmosphereSchlenk technique; Reagent/catalystSolvent; regioselective reaction;
参考文献
Lonzi, Giacomo; Lopez, Luis A.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 1948 - 1954
反应条件
in dimethyl sulfoxide T=150°C; 24 h; Inert atmosphere;
参考文献
Bellur, Esen; Yawer, Mirza A.; Hussain, Ibrar; Riahi, Abdolmajid; Fatunsin, Olumide; Fischer, Christine; Langer, Peter
Synthesis, 2009 , # 2 p. 227 - 242
