1-甲基-5-硝基-2-羟甲基咪唑合成路线 （共 11 条）
反应条件
in dimethyl sulfoxide
参考文献
Adebayo, Adelaide T. O. M.; Bowman, W. Russell; Salt, W. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2819 - 2828
反应条件
ammonia; potassium carbonate in methanol T=50°C; 18 h;
参考文献
ANGIOGENE PHARMACEUTICALS LIMITED; THE GRAY LABORATORY CANCER RESEARCH TRUST
Patent: WO2006/32921 A1, 2006 ;
Location in patent: Page/Page column 35-36 ;
反应条件
sodium tetrahydroborate in ethanol; dichloromethane T=20°C; Reduction; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 11 p. 2258 - 2265
反应条件
in dimethyl sulfoxide
反应条件
1.1: ozone / CH2Cl2; methanol / 2 h / -78 °C 1.2: 51 percent / dimethyl sulfide / CH2Cl2; methanol / -78 - 20 °C 2.1: sodium borohydride / ethanol; CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 11 p. 2258 - 2265
反应条件
1.1: 91 percent / trifluoroacetic acid / dimethylformamide / 12 h / 100 °C 2.1: ozone / CH2Cl2; methanol / 2 h / -78 °C 2.2: 51 percent / dimethyl sulfide / CH2Cl2; methanol / -78 - 20 °C 3.1: sodium borohydride / ethanol; CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 11 p. 2258 - 2265
反应条件
1: 90 percent / manganese dioxide / CHCl3 / 2 h 2: 65 percent / diethyl ether / 1 h View Scheme
参考文献
Shafiee; Pirouzzadeh; Ghasemian; Parang
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 1021 - 1023
反应条件
1: thionyl chloride / ethanol; dichloromethane / 0 °C / Reflux 2: caesium carbonate; potassium iodide / acetonitrile / 80 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1015 - 1018
反应条件
thionyl chloride in ethanol; dichloromethane
T=0°C; Reflux;
参考文献
Samant, Bhupesh S.; Sukhthankar, Mugdha G.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1015 - 1018
反应条件
manganese(IV) oxide in chloroform
2 h;
参考文献
Shafiee; Pirouzzadeh; Ghasemian; Parang
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 1021 - 1023
