1-(4-甲氧基苯基)吲哚合成路线 （共 15 条）
反应条件
N-chloro-succinimide; phosphoric acid; acetic acid 1.) CH2Cl2, 2.) reflux; Yield given. Multistep reaction;
参考文献
Pfizer Inc.
Patent: US4476307 A1, 1984 ;
反应条件
copper(l) iodide; 1-Hydroxymethyl-1H-benzotriazole; potassium tert-butylate in dimethyl sulfoxide
T=110°C; Inert atmosphere;
参考文献
Verma, Akhilesh Kumar; Kesharwani, Tanay; Singh, Jaspal; Tandon, Vibha; Larock, Richard C.
Angewandte Chemie - International Edition, 2009 , vol. 48, # 6 p. 1138 - 1143
反应条件
[Cu8(H){S2P(OiPr)2}6](PF6); caesium carbonate in N,N-dimethyl-formamide
T=105°C; Ullmann-Goldberg type coupling; 24 h;
参考文献
Wu, Cheng-Chieh; Lee, Bo-Han; Liao, Ping-Kuei; Fang, Ching-Shiang; Liu
Journal of the Chinese Chemical Society, 2012 , vol. 59, # 4 p. 480 - 484
反应条件
potassium fluoride; caesium carbonate; 2-(di-tert-butylphosphino)-2'-isopropylbiphenyl; palladium diacetate; carbon dioxide
T=100°C; P=93086.6 Torr; 17 h;
参考文献
CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED; ASTRAZENECA UK LIMITED
Patent: WO2005/90283 A1, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) in toluene
T=80°C; 6 h;
参考文献
Willis, Michael C.; Brace, Gareth N.; Findlay, Thomas J. K.; Holmes, Ian P.
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 7-8 p. 851 - 856
反应条件
C22H26Cl2NPPd; sodium t-butanolate in toluene
T=110°C; 22 h; Inert atmosphere;
参考文献
Samblanet, Danielle C.; Schmidt, Joseph A. R.
Journal of Organometallic Chemistry, 2012 , vol. 720, p. 7 - 18,12
反应条件
Rb2CO3; tri-tert-butyl phosphine; palladium diacetate in xylene
T=120°C; Condensation; 24 h;
参考文献
Watanabe, Makoto; Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki
Tetrahedron Letters, 2000 , vol. 41, # 4 p. 481 - 483
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; palladium diacetate in toluene
T=110°C; 48 h;
参考文献
Bellina, Fabio; Benelli, Francesca; Rossi, Renzo
Journal of Organic Chemistry, 2008 , vol. 73, # 14 p. 5529 - 5535
反应条件
copper(l) iodide; potassium carbonate in N,N-dimethyl-formamide
T=140 - 150°C; 7 h;
参考文献
Zhou, Tao; Chen, Zhen-Chu
Synthetic Communications, 2002 , vol. 32, # 6 p. 903 - 907
反应条件
t-Bu-BippyPhos; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; sodium t-butanolate in toluene
T=110°C; Buchwald-Hartwig Coupling; 12 h; Inert atmosphereGlovebox;
参考文献
Crawford, Sarah M.; Lavery, Christopher B.; Stradiotto, Mark
Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16760 - 16771
