benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=-5 - 23°C; 12.25 h; Inert atmosphereLarge scale; TemperatureSolvent;

benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-5°C;

1: sodium hydroxide; water / tetrahydrofuran / 2.16 h / 0 - 20 °C 2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / pH 8.5 3: palladium 10 on activated carbon; hydrogen / methanol / 48 h / 760.05 Torr 4: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12.25 h / -5 - 23 °C / |Inert atmosphere; |Large scale View Scheme

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / pH 8.5 2: palladium 10 on activated carbon; hydrogen / methanol / 48 h / 760.05 Torr 3: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12.25 h / -5 - 23 °C / |Inert atmosphere; |Large scale View Scheme

1: dichloromethane / 20 °C / |Inert atmosphere; |Cooling with ice; |Large scale 2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12.25 h / -5 - 23 °C / |Inert atmosphere; |Large scale View Scheme

1: dichloromethane / 3.08 h / 0 °C 2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / pH 8.5 3: palladium 10 on activated carbon; hydrogen / methanol / 48 h / 760.05 Torr 4: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12.25 h / -5 - 23 °C / |Inert atmosphere; |Large scale View Scheme

1: palladium 10 on activated carbon; hydrogen / methanol / 48 h / 760.05 Torr 2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12.25 h / -5 - 23 °C / |Inert atmosphere; |Large scale View Scheme