N-甲基-R-α-甲基-[3,5-二(三氟甲基)]苄胺·L-苹果酸盐合成路线 (共 2 条)
反应条件
sodium carbonate in ethanol; water; ethyl acetate T=20 - 25°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/48642 A1, 2007 ;
Location in patent: Page/Page column 9 ;
反应条件
in ethyl acetate; isopropyl alcohol; toluene
T=4 - 75°C; 8.5 h;
参考文献
AVECIA PHARMACEUTICALS LIMITED
Patent: WO2006/67395 A1, 2006 ;
Location in patent: Page/Page column 23-24 ;