甲基 1-boc-3-氟哌啶-3-羧酸合成路线 （共 3 条）
反应条件
1: With water; sodium hydroxide in methanol T=20°C; 2 h; 2: With hydrogenchloride in methanol; water
参考文献
NOVARTIS AG; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; NG, Simon C.; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James
Patent: WO2012/101063 A1, 2012 ;
Location in patent: Page/Page column 145 ;
WO 2012/101063 A1
反应条件
N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide; lithium diisopropyl amide in tetrahydrofuran; hexane
T=0°C; 20.75 h;
参考文献
NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin
Patent: WO2011/26917 A1, 2011 ;
Location in patent: Page/Page column 67-68 ;
WO 2011/026917 A1
反应条件
1: piperidine-1,3-dicarboxylic acid 1-tert-butyl ester-3-methyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran
T=0°C;
2: N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide T=0 - 20°C; 20.25 h;
参考文献
NOVARTIS AG; BARSANTI, Paul A.; HU, Cheng; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James
Patent: WO2011/26904 A1, 2011 ;
Location in patent: Page/Page column 66-67 ;
WO 2011/026904 A1
